Opportunity Information: Apply for PA 18 610
The National Institutes of Health (NIH) funding opportunity titled "Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R43/R44 Clinical Trial Not Allowed)" (Funding Opportunity Number PA 18-610) supports Small Business Innovation Research (SBIR) projects aimed at creating better ways to preserve and later revive valuable genetic lines of fruit flies (Drosophila) and zebrafish. The central goal is technology development: applicants are expected to propose innovative methods, tools, or systems that enable cryogenic preservation or other long-term storage approaches, with a clear path to reliably bringing those genetic stocks back to life and use. The FOA emphasizes that the resulting technologies should be dependable in practice, reproducible across runs and users, and cost-effective enough to be adopted broadly for routine stock preservation.
The opportunity is focused on protecting both wild-type stocks and genetically engineered or laboratory-created lines, which are widely used in biomedical and basic research. Because maintaining living colonies can be expensive and risky (losses can occur from contamination, genetic drift, equipment failures, or simple husbandry errors), the NIH is encouraging small businesses to develop preservation and revival solutions that reduce these vulnerabilities and improve long-term stewardship of these research resources. While cryopreservation is explicitly highlighted, the language also leaves room for other long-term preservation strategies, as long as they meet the practical performance expectations: long storage duration, consistent recovery, and reasonable cost.
This announcement uses the SBIR mechanism and is limited to eligible small business concerns, reflecting NIH's intent to stimulate commercialization-oriented research and development. The listed grant mechanisms are R43 and R44, which typically correspond to SBIR Phase I (feasibility and early proof-of-concept) and Phase II (full research and development effort), respectively, allowing a project to progress from initial demonstration to more advanced development and validation. The FOA is explicitly labeled "Clinical Trial Not Allowed," meaning proposed work must not include clinical trials; the work is intended to be preclinical and technology-focused, centered on preservation and revival methods for these model organisms rather than human subject testing.
Eligibility is restricted to U.S. small businesses. Non-domestic (non-U.S.) entities, including foreign institutions, are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible to apply. However, the FOA notes that "foreign components" may be allowed as defined by the NIH Grants Policy Statement, which generally means limited, well-justified parts of a project may occur outside the United States under NIH rules, but the applicant organization itself must be eligible and domestic.
Administratively, this is a discretionary grant opportunity offered by the NIH within the health funding activity category (CFDA 93.351). The original closing date listed for the opportunity was 2021-01-05, and the opportunity was created on 2018-01-31. The source data provided does not specify an award ceiling or expected number of awards, suggesting those details may vary by application cycle, available appropriations, and NIH program priorities at the time of review.Apply for PA 18 610
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R43/R44 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351.
- This funding opportunity was created on 2018-01-31.
- Applicants must submit their applications by 2021-01-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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FAQs: NIH SBIR PA-18-610 - Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R43/R44, Clinical Trial Not Allowed)
1) What is the title of this NIH funding opportunity?
The opportunity is titled "Development of Novel and Emerging Technologies for Cryogenic or Long-term Preservation and Revival of Drosophila and Zebrafish Genetic Stocks (R43/R44 Clinical Trial Not Allowed)."
2) What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA 18-610.
3) What is the main purpose of this FOA?
The purpose is to support SBIR projects that develop improved technologies to preserve and later revive valuable genetic stocks of Drosophila (fruit flies) and zebrafish. The emphasis is on practical, reliable, and broadly adoptable technology development.
4) What kinds of organisms and research resources does this opportunity focus on?
This FOA focuses specifically on genetic stocks (lines) of Drosophila and zebrafish, including both wild-type stocks and genetically engineered or laboratory-created lines used widely in biomedical and basic research.
5) What types of preservation approaches are encouraged?
Cryogenic preservation (cryopreservation) is explicitly highlighted. The FOA also allows for other long-term preservation strategies, as long as they can support long storage duration, consistent recovery, and reasonable cost for routine use.
6) What does NIH mean by "preservation and revival" in this context?
It means not only storing Drosophila or zebrafish genetic stocks for the long term, but also having a clear and reliable path to bringing those stocks back into use (revival) in a way that works consistently in practice.
7) What are the key performance expectations for the technologies developed under this FOA?
The FOA emphasizes that resulting technologies should be dependable in practice, reproducible across runs and users, and cost-effective enough to be adopted broadly for routine stock preservation. It also emphasizes long storage duration and consistent recovery.
8) Why is NIH encouraging this type of technology development?
Maintaining living colonies of Drosophila and zebrafish can be expensive and vulnerable to loss from contamination, genetic drift, equipment failures, or husbandry errors. This FOA aims to reduce those risks and improve long-term stewardship of important research resources.
9) What grant mechanism is used for this opportunity?
This announcement uses the Small Business Innovation Research (SBIR) mechanism.
10) What do the R43 and R44 mechanisms mean here?
The FOA lists R43 and R44, which typically correspond to SBIR Phase I (feasibility and early proof-of-concept) and SBIR Phase II (a fuller research and development effort). This structure supports progression from initial demonstration to more advanced development and validation.
11) Are clinical trials allowed under this FOA?
No. The FOA is labeled "Clinical Trial Not Allowed," meaning proposed work must not include clinical trials. The intent is preclinical, technology-focused work centered on preservation and revival methods for these model organisms rather than human subject testing.
12) Who is eligible to apply?
Eligibility is restricted to U.S. small business concerns.
13) Are non-U.S. (foreign) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities, including foreign institutions, are not eligible to apply.
14) Can a U.S. small business include work performed outside the United States?
The FOA states that "non-domestic components" of U.S. organizations are not eligible. However, it also notes that "foreign components" may be allowed as defined by the NIH Grants Policy Statement, meaning limited, well-justified parts of a project may occur outside the U.S. under NIH rules while the applicant organization remains domestic and eligible.
15) What NIH funding activity category and CFDA number are associated with this opportunity?
This is an NIH discretionary grant opportunity within the health funding activity category. The CFDA number provided is 93.351.
16) When was this opportunity created?
The opportunity was created on 2018-01-31.
17) What is the closing date listed in the provided information?
The original closing date listed is 2021-01-05.
18) Does the provided information include an award ceiling or the expected number of awards?
No. The source data provided does not specify an award ceiling or expected number of awards, and notes that these details may vary by application cycle, available appropriations, and NIH program priorities at the time of review.
19) What is NIH most interested in funding through this FOA?
NIH is most interested in commercialization-oriented technology development that leads to practical preservation and revival solutions for Drosophila and zebrafish genetic stocks, with strong emphasis on reliability, reproducibility, long-term storage performance, and affordability for routine adoption.
20) Is this opportunity focused on maintaining living colonies?
No. The FOA is aimed at developing preservation and revival solutions that reduce reliance on continuously maintaining living colonies and reduce the risks associated with doing so.
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