Opportunity Information: Apply for PAR 21 280
The National Institutes of Health (NIH) funding opportunity titled "Dyadic Interpersonal Processes and Biopsychosocial Outcomes (R01 - Basic Experimental Studies with Humans)" (PAR-21-280) supports R01 grant applications that focus on how two people affect each other in ways that matter for health. In this announcement, a "dyad" is defined as a unit of two individuals whose interactions and mutual influences unfold within broader social contexts and networks. The central idea is to move beyond studying individuals in isolation and instead examine health-relevant processes that are independent (effects within each person) and interdependent (spillover or crossover effects between the two people), including how those effects can be measured, explained, and experimentally shaped.
This FOA is specifically intended for basic and/or methodological research in humans that uses prospective experimental designs. That means applicants are expected to assign human participants to conditions in advance and deliberately manipulate one or more independent variables, then measure biomedical and/or behavioral outcomes to clarify fundamental mechanisms operating inside the dyad. NIH frames these projects as basic science studies involving human participants that still meet the NIH definition of a clinical trial, because there is prospective assignment and an intervention or manipulation is being tested for its effect on outcomes. In practical terms, the work might involve experimentally altering some aspect of dyadic interaction, communication, coordination, support, stress exposure, or decision-making, and then assessing downstream effects on relevant outcomes such as physiology, symptoms, affect, cognition, behavior, or other health-linked endpoints, with attention to how each partner influences the other.
The announcement also draws a clear boundary around what should not be submitted under this specific FOA. Studies that rely on model animals, purely observational human designs, or analyses of existing or synthesized datasets are directed instead to a companion R01 announcement labeled "Clinical Trials Not Allowed" (referenced in the text as PAR-XX-XXX). In other words, PAR-21-280 is for projects that experimentally manipulate conditions in studies with humans and therefore qualify as clinical trials under NIH rules, even though the scientific intent is basic rather than intervention effectiveness in the typical clinical sense.
Eligibility is broad and includes many types of organizations that commonly apply to NIH, such as public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and a wide range of governmental entities (state, county, city/township, special districts, independent school districts), as well as public housing authorities and Indian housing authorities. The FOA also explicitly highlights additional eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and certain tribal governments or organizations (including some that are not federally recognized). Foreign (non-U.S.) entities are also listed among the additional eligible applicants, indicating NIH is open to non-domestic organizational participation where allowable under NIH policy and the specific institute/center involved.
From an administrative standpoint, this is a discretionary NIH grant mechanism (R01). The opportunity is associated with multiple CFDA numbers (93.121, 93.242, 93.273, 93.279, 93.307, 93.313, 93.399, 93.865, 93.866), reflecting that multiple NIH institutes and centers may participate depending on the scientific fit. The posting lists an original closing date of 2023-05-07 and a creation date of 2021-07-09. An award ceiling and expected number of awards are not specified in the provided source data, which is common for NIH FOAs where budgets depend on the scope, IC priorities, and availability of funds rather than a fixed cap.
Overall, this FOA is aimed at researchers who want to rigorously test and measure causal mechanisms in two-person social relationships, using experimental methods in humans, and link those dyadic processes to meaningful biopsychosocial outcomes. It is best suited for proposals where the dyad is not just a recruitment convenience (two people enrolled together), but the actual unit of interest, with research questions and analytic plans designed to capture how partners shape each other over time and under manipulated conditions.Apply for PAR 21 280
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Dyadic Interpersonal Processes and Biopsychosocial Outcomes (R01 - Basic Experimental Studies with Humans)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.242, 93.273, 93.279, 93.307, 93.313, 93.399, 93.865, 93.866.
- This funding opportunity was created on 2021-07-09.
- Applicants must submit their applications by 2023-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional) Apply for RFA MH 21 205 Funding Number: RFA MH 21 205 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| BRAIN Initiative Cell Atlas Network (BICAN): Specialized Collaboratory on Human, Non-human Primate, and Mouse Brain Cell Atlases (U01 Clinical Trial Not Allowed) Apply for RFA MH 21 236 Funding Number: RFA MH 21 236 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative Cell Atlas Network (BICAN): Comprehensive Center on Human and Non-human Primate Brain Cell Atlases (UM1 Clinical Trial Not Allowed) Apply for RFA MH 21 235 Funding Number: RFA MH 21 235 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative Cell Atlas Network (BICAN): Coordinating Unit for Biostatistics, Informatics, and Engagement (CUBIE) (U24 Clinical Trial Not Allowed) Apply for RFA MH 21 237 Funding Number: RFA MH 21 237 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| American Women: Assessing Risk Epidemiologically (AWARE) (R01 Clinical Trial Optional) Apply for RFA AI 21 058 Funding Number: RFA AI 21 058 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional) Apply for PAR 21 315 Funding Number: PAR 21 315 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Blueprint MedTech: Incubator Hubs (U54 Clinical Trial Not Allowed) Apply for PAR 21 314 Funding Number: PAR 21 314 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Interventions for Stigma Reduction to Improve HIV/AIDS Prevention, Treatment and Care in Low- and Middle- Income Countries (R01 - Clinical Trial Optional) Apply for PAR 21 344 Funding Number: PAR 21 344 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $400,000 |
| INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Exploratory/Developmental Research Grant Award (R21 Clinical Trial Not Allowed) Apply for RFA OD 21 007 Funding Number: RFA OD 21 007 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Clinical Trials Not Allowed) Apply for PAR 21 350 Funding Number: PAR 21 350 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Basic Experimental Studies with Humans Required) Apply for PAR 21 349 Funding Number: PAR 21 349 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on Biopsychosocial Factors of Social Connectedness and Isolation on Health, Wellbeing, Illness, and Recovery (R01 Clinical Trial Required) Apply for PAR 21 352 Funding Number: PAR 21 352 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Pre-application: Opportunities for Collaborative Research at the NIH Clinical Center (X02 Clinical Trial Optional) Apply for PAR 21 342 Funding Number: PAR 21 342 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| Opportunities for Collaborative Research at the NIH Clinical Center (U01 Clinical Trial Optional) Apply for PAR 21 343 Funding Number: PAR 21 343 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed) Apply for RFA NS 22 011 Funding Number: RFA NS 22 011 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional) Apply for RFA HD 23 021 Funding Number: RFA HD 23 021 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $6,250,000 |
| Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Scientific Leadership Center (UM2 Clinical Trial Optional) Apply for RFA HD 23 020 Funding Number: RFA HD 23 020 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $6,875,000 |
| BRAIN Initiative-Related Research Education: Short Courses (R25 Clinical Trial Not Allowed) Apply for RFA EY 21 003 Funding Number: RFA EY 21 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $250,000 |
| HEAL Initiative: National K12 Clinical Pain Career Development Program (K12 Clinical Trial Not Allowed) Apply for RFA NS 22 045 Funding Number: RFA NS 22 045 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required) Apply for PAR 21 357 Funding Number: PAR 21 357 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
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