Opportunity Information: Apply for RFA DA 22 044
The HEAL Initiative funding opportunity "Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic" (RFA-DA-22-044) is a National Institutes of Health (NIH) R01 grant aimed at strengthening how opioid-related information is captured, combined, and used to guide public health and clinical responses. The central goal is to fund research that creates or improves methods for obtaining, extracting, linking, or aggregating data from existing sources so that researchers and decision-makers can understand opioid misuse, opioid use disorder, treatment, recovery, relapse, and related outcomes more quickly and accurately. A key theme is speed and practicality: projects are expected to reduce the time lag between when real-world events occur and when usable data become available, while also making surveillance and clinical data more efficient and actionable for prevention and treatment efforts.
The FOA emphasizes method and data-stream innovation rather than running clinical trials, and it is explicitly labeled "Clinical Trial Not Allowed." In practical terms, the work supported here is about advancing data methods and analytics using already-existing data streams, such as electronic health records (EHR), insurance claims, registries, pharmacy dispensing data, and mortality records. Competitive projects would typically focus on better ways to pull information from these systems, harmonize variables across sources, improve linkage across settings (for example, connecting clinical care data to overdose mortality), and generate near-real-time indicators that can help identify emerging risks or evaluate the impact of interventions and policy changes. The intent is to enable faster situational awareness of the opioid epidemic and to produce insights that can be translated into improved prevention strategies, service delivery, and treatment planning.
Eligible applicants are broad and include many types of U.S.-based organizations and governments. Public sector applicants may include state, county, city or township governments, special district governments, and independent school districts, as well as public housing authorities and Indian housing authorities. Higher-education institutions are eligible across categories, including public and state-controlled institutions of higher education and private institutions of higher education. Tribal eligibility is also included, covering federally recognized Native American tribal governments and Native American tribal organizations other than federally recognized tribal governments. The FOA also allows applications from nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (in both cases, other than institutions of higher education), as well as for-profit organizations (other than small businesses) and small businesses. Beyond these standard categories, the announcement specifically highlights additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Foreign participation is clearly restricted. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible either. In addition, foreign components, as defined by the NIH Grants Policy Statement, are not allowed. This means the funded work must be led by eligible U.S.-based applicants and carried out without foreign components as part of the supported project structure.
Administratively, this is a discretionary grant mechanism under the NIH with activity aligned to education and health and associated with CFDA numbers 93.121, 93.213, 93.279, 93.846, and 93.866. The funding opportunity was created on December 20, 2021, with an original closing date of March 10, 2022. The source information provided does not list an award ceiling or the expected number of awards, so those specifics are not available from the supplied excerpt. Overall, the opportunity is designed to accelerate the opioid field's ability to use existing health and administrative data in smarter, faster, and more integrated ways, producing method-focused advances that can inform real-world prevention and treatment responses without conducting clinical trials under this mechanism.Apply for RFA DA 22 044
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HEAL Initiative: Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R01- Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.213, 93.279, 93.846, 93.866.
- This funding opportunity was created on 2021-12-20.
- Applicants must submit their applications by 2022-03-10. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The funding opportunity is titled "Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic" and is associated with the HEAL Initiative.
What is the FOA number?
The FOA number is RFA-DA-22-044.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) grant opportunity.
What grant mechanism does this opportunity use?
The opportunity uses the NIH R01 research project grant mechanism.
What is the main goal of this opportunity?
The central goal is to strengthen how opioid-related information is captured, combined, and used so researchers and decision-makers can understand opioid misuse, opioid use disorder, treatment, recovery, relapse, and related outcomes more quickly and accurately.
What types of research does this FOA aim to fund?
The FOA focuses on creating or improving methods for obtaining, extracting, linking, or aggregating data from existing sources. It emphasizes data-method and data-stream innovation to make surveillance and clinical data more efficient and actionable for prevention and treatment efforts.
Is this opportunity focused on speed or real-time data improvements?
Yes. A key theme is speed and practicality. Projects are expected to reduce the time lag between real-world events and when usable data become available, including developing near-real-time indicators to support situational awareness of the opioid epidemic.
Are clinical trials allowed under this FOA?
No. The FOA is explicitly labeled "Clinical Trial Not Allowed."
If clinical trials are not allowed, what kinds of work are considered a fit?
The supported work is about advancing data methods and analytics using already-existing data streams. Examples include improving how data are extracted, harmonizing variables across sources, enhancing linkage across settings, and producing timely indicators that inform prevention strategies, service delivery, and treatment planning.
What kinds of existing data sources does the FOA mention?
The FOA references existing data streams such as electronic health records (EHR), insurance claims, registries, pharmacy dispensing data, and mortality records.
Does the FOA encourage linking data across settings?
Yes. Competitive projects would typically include improved linkage across settings, such as connecting clinical care data to overdose mortality information.
What kinds of outcomes or topics should the data methods help measure or understand?
The methods should support faster and more accurate understanding of opioid misuse, opioid use disorder, treatment, recovery, relapse, and related outcomes.
How are the results intended to be used?
The intent is to enable faster situational awareness of the opioid epidemic and generate insights that can be translated into improved prevention strategies, service delivery, and treatment planning.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and government entities, including public sector governments, higher-education institutions, tribal entities, nonprofits, and for-profit organizations (including small businesses), subject to the restrictions described in the announcement.
Which U.S. government entities are eligible applicants?
Eligible public sector applicants may include state, county, city or township governments, special district governments, independent school districts, public housing authorities, and Indian housing authorities.
Are colleges and universities eligible?
Yes. Eligible higher-education applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes federally recognized Native American tribal governments and Native American tribal organizations other than federally recognized tribal governments.
Are nonprofit organizations eligible?
Yes. The FOA allows applications from nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (in both cases, other than institutions of higher education).
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) and small businesses are listed as eligible applicants.
Does the FOA highlight specific types of institutions or organizations as eligible?
Yes. The announcement specifically highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are specifically included among eligible applicants.
Are foreign organizations allowed to apply?
No. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
Can a U.S. organization include a non-U.S. (non-domestic) component on the project?
No. Non-domestic components of U.S. organizations are not eligible under this opportunity.
Are foreign components permitted in any form?
No. Foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
What type of grant is this considered administratively?
It is described as a discretionary grant mechanism under the NIH, with activity aligned to education and health.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.121, 93.213, 93.279, 93.846, and 93.866.
When was this funding opportunity created?
The opportunity was created on December 20, 2021.
What was the original closing date listed for the opportunity?
The original closing date listed is March 10, 2022.
Does the provided information include an award ceiling?
No. The provided source information does not list an award ceiling.
Does the provided information include the expected number of awards?
No. The provided source information does not include the expected number of awards.
In one sentence, what is this opportunity trying to accelerate?
It is designed to accelerate the opioid field's ability to use existing health and administrative data in smarter, faster, and more integrated ways, producing method-focused advances that can inform real-world prevention and treatment responses without conducting clinical trials.
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Previous opportunity: Limited Competition: NIH Health Care Systems Research Collaboratory - Coordinating Center (U24 Clinical Trial Not Allowed)
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| Funding Opportunity |
|---|
| HEAL Initiative: Exploratory Data and Methods to Address Urgent Needs to Stem the Opioid Epidemic (R21- Clinical Trial Not Allowed) Apply for RFA DA 22 045 Funding Number: RFA DA 22 045 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Pilot and Feasibility Trials to Improve Prevention and Treatment Service Delivery for Polysubstance Use (R34 Clinical Trial Optional) Apply for RFA DA 22 048 Funding Number: RFA DA 22 048 Agency: National Institutes of Health Category: Education, Health Funding Amount: $225,000 |
| HEAL Initiative: Understanding Polysubstance Use and Improving Service Delivery to Address Polysubstance Use (R01 Clinical Trial Optional) Apply for RFA DA 22 047 Funding Number: RFA DA 22 047 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| HEAL Initiative: Research Networks for the Study of Recovery Support Services for Persons Treated with Medications for Opioid Use Disorder (R24 Clinical Trial Optional) Apply for RFA DA 22 043 Funding Number: RFA DA 22 043 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| HEAL Initiative: Harm Reduction Policies, Practices, and Modes of Delivery for Persons with Substance Use Disorders (R01 Clinical Trial Optional) Apply for RFA DA 22 046 Funding Number: RFA DA 22 046 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| HEAL Initiative: Harm Reduction Policies, Practices, and Modes of Delivery for Persons with Substance Use Disorders: Coordination Center (R24 Clinical Trial Optional) Apply for RFA DA 22 042 Funding Number: RFA DA 22 042 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| HEAL Initiative: Planning Grants for Efficacy or Effectiveness Trials of Recovery Support Services for Individuals Treated with Medications for Opioid Use Disorder (R34 Clinical Trial Optional) Apply for RFA DA 22 034 Funding Number: RFA DA 22 034 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| HEAL Initiative: HEAL Data2Action Innovation Projects (R61/R33 Clinical Trial Optional) Apply for RFA DA 22 051 Funding Number: RFA DA 22 051 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: HEAL Data2Action Modeling and Economic Resource Center (U24 Clinical Trial Optional) Apply for RFA DA 22 049 Funding Number: RFA DA 22 049 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Advancing communication strategies to support future HIV vaccine use (R01 Clinical Trial Optional) Apply for RFA MH 22 170 Funding Number: RFA MH 22 170 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P01 Clinical Trial Optional) Apply for RFA CA 22 008 Funding Number: RFA CA 22 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U54 Clinical Trials Optional) Apply for RFA CA 22 007 Funding Number: RFA CA 22 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U2C Clinical Trial Optional) Apply for RFA CA 22 010 Funding Number: RFA CA 22 010 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications for Incorporation of Novel NCI- Supported Technology to Accelerate Cancer Research (U01 Clinical Trial Optional) Apply for RFA CA 22 006 Funding Number: RFA CA 22 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional) Apply for RFA CA 22 005 Funding Number: RFA CA 22 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| HEAL Initiative: HEAL Data2Action (HD2A) Data Infrastructure Support Center (U24 Clinical Trial Optional) Apply for RFA DA 22 052 Funding Number: RFA DA 22 052 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| HEAL Initiative: HEAL Data2Action Research Adoption Support Center (U2C Clinical Trial Optional) Apply for RFA DA 22 050 Funding Number: RFA DA 22 050 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,000,000 |
| Advancing communication strategies to support future HIV vaccine use (R21 Clinical Trial Optional) Apply for RFA MH 22 171 Funding Number: RFA MH 22 171 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Revision Applications for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P50 Clinical Trial Optional) Apply for RFA CA 22 009 Funding Number: RFA CA 22 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| U.S. and Low- and Middle-Income Country (LMIC) HIV-Associated Malignancy Research Centers (U54 Clinical Trial Optional) Apply for RFA CA 22 011 Funding Number: RFA CA 22 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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