Laboratory of Developmental Biology (R24 Clinical Trial Not Allowed) | PAR 22 229

Opportunity Information: Apply for PAR 22 229

The National Institutes of Health (NIH) funding opportunity PAR-22-229, titled "Laboratory of Developmental Biology (R24 Clinical Trial Not Allowed)," is a discretionary grant designed to maintain and support an established research resource that serves the broader biomedical research community. The central goal is to sustain a program capable of collecting, identifying, staging, and distributing conceptal tissues so that scientists can better investigate the developmental biology of both normal and abnormal human development, along with developmental processes relevant to human disease and pathology. In practical terms, the award is meant to keep a specialized, community-facing laboratory resource running at a high level, ensuring that properly characterized tissues are available to qualified researchers who need them for foundational studies of early human development and related disorders.

This FOA uses the NIH R24 activity mechanism, which is typically intended for research resource-related projects that provide a service or infrastructure benefiting many investigators rather than supporting a single, narrow research project. The emphasis on collection and distribution indicates a strong expectation that the funded program will function as a reliable, centralized resource: obtaining conceptal tissues, applying standardized methods to identify and stage them, documenting key metadata and quality attributes, and then distributing those materials in a way that is useful and consistent for downstream studies across the community. The stated purpose also highlights that the tissues are intended to enable research into mechanisms of development and disease, meaning the resource should be built around scientific rigor, standardized characterization, and broad utility.

The opportunity is explicitly labeled "Clinical Trial Not Allowed," which means applications should not propose clinical trials as part of the project scope. The supported activities are focused on the operation of a research resource and the preparation and provision of biological materials for research use, rather than testing interventions in human participants. Applicants should therefore frame their aims around resource generation, tissue handling and characterization, quality systems, and responsible distribution practices, not clinical testing.

Eligibility is broad across U.S.-based organizational types, reflecting NIH's interest in ensuring that an appropriate institution can house and operate this kind of specialized program. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (as long as they are not institutions of higher education, since those are listed separately); for-profit organizations other than small businesses; small businesses; and other entities. The FOA also highlights additional eligible applicant categories such as historically black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander serving institutions (AANAPISISs), along with faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions.

At the same time, the announcement draws a firm line on foreign involvement. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply. Non-domestic components of U.S. organizations are also not eligible. In addition, foreign components, as defined by the NIH Grants Policy Statement, are not allowed. Taken together, these restrictions mean that the applicant organization must be U.S.-based and the project work must be conducted without foreign components under NIH definitions, which is important for applicants that operate internationally or maintain overseas facilities.

The funding instrument is a grant, and the activity category is listed under Health, Income Security and Social Services. The associated CFDA numbers are 93.242, 93.855, and 93.865, which correspond to NIH assistance listings relevant to the scientific and administrative context for this program. The listed award ceiling is $800,000, indicating the maximum award amount expected under this FOA. The opportunity was created on August 18, 2022, and the original closing date is shown as November 2, 2022, which signals that the specific submission window provided in the source information has passed, although NIH sometimes reissues similar opportunities or continues programs through future announcements.

Overall, the FOA is best understood as NIH support for a long-running, high-value developmental biology resource that provides well-characterized conceptal tissues to researchers. The expected impact is not limited to a single lab's output; instead, it is aimed at strengthening the entire research ecosystem by ensuring access to appropriately staged and identified tissues that can power a wide range of studies on human development and disease mechanisms, while keeping the project squarely in the realm of research resource support rather than clinical trial activity.

• The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Laboratory of Developmental Biology (R24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.855, 93.865.
• This funding opportunity was created on 2022-08-18.
• Applicants must submit their applications by 2022-11-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $800,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 22 229

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