Opportunity Information: Apply for PA 17 220
The Mechanisms of Alcohol-associated Cancers (R01) opportunity (Funding Opportunity Number PA-17-220) is an NIH discretionary grant announcement that supports research aimed at explaining, in concrete cellular and molecular terms, how alcohol consumption increases the risk of developing cancer. The FOA is grounded in the well-established public health finding that alcohol is a carcinogen in humans, as classified by the International Agency for Research on Cancer (IARC, 2010 and 2012) and the US Department of Health and Human Services National Toxicology Program (NTP, 2014). In practical terms, NIH is looking for R01-level projects that move beyond broad associations and instead define the biological pathways and mechanisms that connect alcohol exposure to cancer initiation, promotion, and progression.
A central focus of the announcement is on cancers occurring in tissues with strong epidemiologic links to alcohol-related carcinogenesis. The FOA specifically highlights the upper aerodigestive tract, breast, liver, and colon as target sites. Projects proposed under this announcement would generally be expected to clarify why these particular organs are vulnerable, what alcohol (or its metabolites) does inside cells and tissues to increase malignant transformation, and how those effects interact with tissue-specific biology. The emphasis on mechanisms signals interest in studies that can identify causal processes and key molecular events rather than descriptive correlations alone.
NIH also makes clear why this work matters from a prevention and treatment standpoint. By pinpointing the molecular basis of alcohol-related cancer risk, the research supported through this FOA is intended to contribute to improved therapeutic approaches and more effective prevention strategies. Mechanistic insights can reveal actionable targets for intervention, biomarkers of exposure or early carcinogenic change, and biological rationales for risk reduction strategies. The FOA also notes a broader public health implication: better mechanistic evidence could help inform guidance around safer levels of alcohol consumption by strengthening the scientific basis for risk estimates in different tissues and populations.
From an administrative standpoint, this is an R01 research project grant mechanism under NIH, listed under CFDA numbers 93.273 and 93.396, within the broad activity areas of education and health. The FOA record indicates an original closing date of 2020-09-07 and a creation date of 2017-03-13. The award ceiling and expected number of awards are not specified in the provided source data, which typically means applicants should rely on standard NIH R01 policies and the specific institute or center guidance for budget expectations and paylines.
Eligibility is broad and includes many standard applicant types used in NIH grant programs. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; non-federally recognized Native American tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those categories as specified); for-profit organizations other than small businesses; small businesses; and other types of organizations. The FOA also explicitly encourages or recognizes a wide range of additional eligible applicant groups, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-domestic (non-US) entities (foreign organizations), Indian/Native American Tribal Governments (other than federally recognized), and US territories or possessions.
Overall, the opportunity is designed for investigators and organizations that can mount rigorous, hypothesis-driven biomedical research to explain how alcohol contributes to cancer at the mechanistic level, particularly in the upper aerodigestive tract, breast, liver, and colon. The expected payoff is not just academic insight, but practical translation into prevention strategies, therapeutic avenues, and more defensible public health guidance related to alcohol use and cancer risk.Apply for PA 17 220
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Mechanisms of Alcohol-associated Cancers (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.396.
- This funding opportunity was created on 2017-03-13.
- Applicants must submit their applications by 2020-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Revision Applications to National Cancer Institute (NCI)-supported U01 Awards to Include Research on the NCI's Provocative Questions (U01) Apply for RFA CA 17 020 Funding Number: RFA CA 17 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to National Cancer Institute (NCI)-supported P01 Awards to Include Research on the NCI's Provocative Questions (P01) Apply for RFA CA 17 021 Funding Number: RFA CA 17 021 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to National Cancer Institute (NCI)-supported P50 Awards to Include Research on the NCI's Provocative Questions (P50) Apply for RFA CA 17 022 Funding Number: RFA CA 17 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revision Applications to NCI-supported R01 Awards to Include Research on the NCI's Provocative Questions (R01) Apply for RFA CA 17 019 Funding Number: RFA CA 17 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
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| Advancing the Science of Geriatric Palliative Care (R21) Apply for PA 17 226 Funding Number: PA 17 226 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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| Mechanisms and Consequences of Sleep Disparities in the U.S. (R21) Apply for PAR 17 235 Funding Number: PAR 17 235 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Innovative Research in Cancer Nanotechnology (IRCN) (R01) Apply for PAR 17 240 Funding Number: PAR 17 240 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
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| Activities to Promote Research Collaborations on Immune-Related Adverse Events (APRC-irAEs) Associated with Cancer Immunotherapy (Admin Supp) Apply for PA 17 248 Funding Number: PA 17 248 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Collaborative Research Projects to Enhance Applicability of Mammalian Models for Translational Research (Collaborative R01) Apply for PAR 17 244 Funding Number: PAR 17 244 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Extracellular Vesicles and Substance Use Disorders (R21) Apply for PAR 17 242 Funding Number: PAR 17 242 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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