Opportunity Information: Apply for HRSA 18 070

The Quality Improvement in Newborn Screening Program (Funding Opportunity Number HRSA 18-070) is a discretionary grant offered by the U.S. Department of Health and Human Services through the Health Resources and Services Administration (HRSA). Its central focus is strengthening how newborn screening (NBS) systems function so that babies who screen positive for serious conditions move more quickly and reliably from an initial screen to appropriate follow-up, diagnosis, and care. The program is built around the idea that even when states and territories are screening for the right conditions, preventable delays or process breakdowns can lead to missed or late diagnoses, which can worsen outcomes for infants and families.

The opportunity targets practical, measurable improvements across key points in the newborn screening pathway. A major priority is reducing the time it takes to identify infants who are at high risk based on screening results, since many screened conditions require rapid intervention to prevent disability, severe illness, or death. It also emphasizes improving the laboratory and program processes used to detect out-of-range results, which can include strengthening analytical workflows, refining cutoffs or decision rules, improving data handling, and reducing errors that could affect result interpretation. Another core aim is improving how out-of-range results are reported to health care providers, recognizing that even an accurate lab finding can lose its value if it is communicated late, sent to the wrong place, or delivered without the clarity needed for immediate clinical action.

Beyond initial identification and notification, the program highlights the need to improve methods used to confirm diagnoses after an abnormal screen. Confirmation often involves additional testing, specialist referral, coordinated follow-up, and tracking to ensure the infant receives timely diagnostic services. Strengthening this phase can reduce loss to follow-up and help ensure that families receive clear guidance and that providers have the information they need to act. The grant also explicitly supports work on emerging issues in newborn screening, as well as any other NBS processes or procedures that might negatively affect the quality, accuracy, or timeliness of screening. This leaves room for addressing new technologies, evolving screening panels, changing clinical guidelines, data system modernization challenges, workforce issues, or cross-jurisdiction coordination problems that can arise as newborn screening programs adapt over time.

HRSA anticipated making a single award under this announcement, with an award ceiling of $3.3 million. The opportunity was listed under CFDA 93.110 and used a grant as the funding instrument. Eligibility is described broadly as "Others," with additional eligibility details referenced in the full announcement. The notice was created on January 18, 2018, with an original application closing date of March 20, 2018. Overall, this funding opportunity is aimed at supporting a high-impact effort to improve the end-to-end performance of newborn screening programs, with the ultimate goal of ensuring that infants with screen-detectable conditions are identified faster, communicated about more effectively, and confirmed and connected to care with fewer delays and fewer preventable failures.

  • The Department of Health and Human Services, Health Resources and Services Administration in the health sector is offering a public funding opportunity titled "Quality Improvement in Newborn Screening Program" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.110.
  • This funding opportunity was created on Jan 18, 2018.
  • Applicants must submit their applications by Mar 20, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $3,300,000.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for HRSA 18 070

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