Opportunity Information: Apply for RFA HL 18 005
Sleep Health and Circadian Biology in HIV-Related Comorbidities (R01) (RFA-HL-18-005) is a National Institutes of Health grant opportunity from the Department of Health and Human Services that supports clinical research aimed at understanding sleep and circadian rhythm problems in people living with HIV, including both adults and children. The core idea is that sleep disorders and circadian disruption are common in HIV and may play a meaningful role in driving, worsening, or interacting with other major HIV-related health issues, particularly conditions affecting the heart, lungs, and blood. This announcement is looking for projects that go beyond describing sleep problems and instead dig into the underlying biology and the mechanistic links between disrupted sleep or circadian timing and downstream cardiopulmonary or hematologic comorbidities seen in HIV.
The scientific focus is explicitly mechanistic. Applicants are expected to test clear hypotheses that connect HIV-associated sleep or circadian disturbances to specific molecular, cellular, or physiological pathways that could plausibly contribute to comorbid disease. Studies can leverage a wide range of tools and resources, including existing clinical cohorts, stored biospecimens and sample repositories, genomic or other -omics approaches, and complementary work in vertebrate animal models. The intention is to encourage research designs that can bridge levels of analysis, for example tying clinical sleep phenotypes or circadian measures to immune or inflammatory signaling, autonomic function, metabolic changes, vascular biology, pulmonary physiology, or hematologic processes that are relevant to HIV-related comorbidities.
A key expectation is interdisciplinary collaboration. Successful applications are meant to bring together expertise across sleep medicine and sleep measurement, circadian biology, HIV clinical and translational research, and the relevant comorbidity domains (heart, lung, and blood). In practical terms, this means the program is geared toward teams that can integrate clinical characterization of sleep and circadian disruption with laboratory and analytic approaches that clarify mediators and mechanisms, rather than treating sleep as an isolated symptom. Projects that can connect patient-level findings with biologic pathways, and then relate those pathways to cardiopulmonary and/or hematologic outcomes, are aligned with the goals of the announcement.
From an administrative and funding standpoint, this is an R01 research project grant in the NIH health category. Eligible applicants are broad and include federal-recognized tribal governments and tribal organizations, state and local governments, public and private institutions of higher education, independent school districts, special district governments, public housing authorities/Indian housing authorities, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses, with additional eligibility details referenced in the full announcement. The stated award ceiling is $350,000, and the opportunity anticipated making about 3 awards. The opportunity was created March 14, 2017, with an original closing date of August 9, 2017. The CFDA numbers associated with this FOA are 93.233, 93.837, 93.838, and 93.839, reflecting the NIH program areas involved.
In short, this FOA funds mechanistically oriented clinical research that explains why sleep and circadian problems occur in HIV and how they may influence, or be influenced by, HIV-related comorbid disease in the heart, lungs, and blood. It encourages investigators to use existing cohorts and biospecimens where possible, combine clinical and biological methods (including genomics and animal models as appropriate), and build interdisciplinary teams capable of linking sleep and circadian science to HIV pathophysiology and comorbidity risk.Apply for RFA HL 18 005
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Sleep Health and Circadian Biology in HIV-Related Comorbidities (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839.
- This funding opportunity was created on Mar 14, 2017.
- Applicants must submit their applications by Aug 09, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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