Opportunity Information: Apply for RFA HL 18 005
Sleep Health and Circadian Biology in HIV-Related Comorbidities (R01) (RFA-HL-18-005) is a National Institutes of Health grant opportunity from the Department of Health and Human Services that supports clinical research aimed at understanding sleep and circadian rhythm problems in people living with HIV, including both adults and children. The core idea is that sleep disorders and circadian disruption are common in HIV and may play a meaningful role in driving, worsening, or interacting with other major HIV-related health issues, particularly conditions affecting the heart, lungs, and blood. This announcement is looking for projects that go beyond describing sleep problems and instead dig into the underlying biology and the mechanistic links between disrupted sleep or circadian timing and downstream cardiopulmonary or hematologic comorbidities seen in HIV.
The scientific focus is explicitly mechanistic. Applicants are expected to test clear hypotheses that connect HIV-associated sleep or circadian disturbances to specific molecular, cellular, or physiological pathways that could plausibly contribute to comorbid disease. Studies can leverage a wide range of tools and resources, including existing clinical cohorts, stored biospecimens and sample repositories, genomic or other -omics approaches, and complementary work in vertebrate animal models. The intention is to encourage research designs that can bridge levels of analysis, for example tying clinical sleep phenotypes or circadian measures to immune or inflammatory signaling, autonomic function, metabolic changes, vascular biology, pulmonary physiology, or hematologic processes that are relevant to HIV-related comorbidities.
A key expectation is interdisciplinary collaboration. Successful applications are meant to bring together expertise across sleep medicine and sleep measurement, circadian biology, HIV clinical and translational research, and the relevant comorbidity domains (heart, lung, and blood). In practical terms, this means the program is geared toward teams that can integrate clinical characterization of sleep and circadian disruption with laboratory and analytic approaches that clarify mediators and mechanisms, rather than treating sleep as an isolated symptom. Projects that can connect patient-level findings with biologic pathways, and then relate those pathways to cardiopulmonary and/or hematologic outcomes, are aligned with the goals of the announcement.
From an administrative and funding standpoint, this is an R01 research project grant in the NIH health category. Eligible applicants are broad and include federal-recognized tribal governments and tribal organizations, state and local governments, public and private institutions of higher education, independent school districts, special district governments, public housing authorities/Indian housing authorities, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses, with additional eligibility details referenced in the full announcement. The stated award ceiling is $350,000, and the opportunity anticipated making about 3 awards. The opportunity was created March 14, 2017, with an original closing date of August 9, 2017. The CFDA numbers associated with this FOA are 93.233, 93.837, 93.838, and 93.839, reflecting the NIH program areas involved.
In short, this FOA funds mechanistically oriented clinical research that explains why sleep and circadian problems occur in HIV and how they may influence, or be influenced by, HIV-related comorbid disease in the heart, lungs, and blood. It encourages investigators to use existing cohorts and biospecimens where possible, combine clinical and biological methods (including genomics and animal models as appropriate), and build interdisciplinary teams capable of linking sleep and circadian science to HIV pathophysiology and comorbidity risk.Apply for RFA HL 18 005
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Sleep Health and Circadian Biology in HIV-Related Comorbidities (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839.
- This funding opportunity was created on Mar 14, 2017.
- Applicants must submit their applications by Aug 09, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Sleep Health and Circadian Biology in HIV-Related Comorbidities (R01) with the identifier RFA-HL-18-005.
Which agency is offering this funding?
This is a National Institutes of Health (NIH) funding opportunity from the U.S. Department of Health and Human Services (HHS).
What type of award is this?
This is an NIH R01 research project grant.
What is the overall goal of this FOA?
The FOA supports clinical research that goes beyond describing sleep problems in people living with HIV and instead explains the mechanisms linking sleep and circadian rhythm disruption to HIV-related cardiopulmonary and/or hematologic comorbidities.
Who is the target population for the supported research?
The focus is on people living with HIV, including adults and children.
What kinds of health conditions are emphasized as HIV-related comorbidities?
The announcement highlights comorbidities affecting the heart, lungs, and blood, and it is particularly interested in how sleep and circadian disruption may drive, worsen, or interact with these conditions.
Is the FOA interested in descriptive studies of sleep problems in HIV?
No. The scientific focus is explicitly mechanistic. Projects are expected to test clear hypotheses that connect HIV-associated sleep or circadian disturbances to specific molecular, cellular, or physiological pathways relevant to comorbid disease.
What does "mechanistic" mean in the context of this FOA?
It means the study should investigate how and why sleep or circadian disruption is linked to downstream outcomes by examining plausible mediators, such as immune/inflammatory signaling, autonomic function, metabolic changes, vascular biology, pulmonary physiology, or hematologic processes that could contribute to HIV-related comorbidities.
What kinds of hypotheses are applicants expected to test?
Applicants are expected to test hypotheses that explicitly connect sleep or circadian disruption in HIV to identifiable biological pathways (molecular, cellular, or physiological) that plausibly contribute to cardiopulmonary and/or hematologic comorbidities.
What research approaches and resources are encouraged?
The FOA encourages use of a wide range of tools and resources, including existing clinical cohorts, stored biospecimens and sample repositories, genomic and other -omics approaches, and complementary vertebrate animal models.
Does this FOA allow animal model work?
Yes. The FOA notes that studies may include complementary work in vertebrate animal models as part of a broader strategy to understand mechanisms.
Is the emphasis purely clinical, or does it include laboratory and analytic components?
While the FOA supports clinical research, it explicitly expects integration with laboratory and analytic approaches that can clarify mediators and mechanisms linking sleep/circadian disruption to HIV-related comorbid outcomes.
What does it mean to "bridge levels of analysis" in this FOA?
It refers to connecting clinical sleep phenotypes or circadian measures to underlying biology (for example, immune or metabolic signaling) and then relating those biological pathways to cardiopulmonary and/or hematologic outcomes relevant to HIV.
Which scientific domains are expected to be integrated?
The FOA emphasizes interdisciplinary work integrating expertise in sleep medicine and sleep measurement, circadian biology, HIV clinical and translational research, and the relevant comorbidity domains in heart, lung, and blood.
How important is interdisciplinary collaboration for this opportunity?
It is a key expectation. The program is geared toward teams that can combine clinical characterization of sleep/circadian disruption with mechanistic laboratory and analytic approaches tied to comorbidity outcomes.
What types of organizations are eligible to apply?
Eligibility is broad and includes: federal-recognized tribal governments and tribal organizations, state and local governments, public and private institutions of higher education, independent school districts, special district governments, public housing authorities/Indian housing authorities, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), and small businesses. Additional eligibility details are referenced in the full announcement.
What is the award ceiling stated in the opportunity summary?
The stated award ceiling is $350,000.
How many awards were anticipated?
The opportunity anticipated making about 3 awards.
When was this opportunity created, and what was the original closing date?
The opportunity was created on March 14, 2017, and the original closing date was August 9, 2017.
What CFDA numbers are associated with this FOA?
The CFDA numbers listed are 93.233, 93.837, 93.838, and 93.839.
What does the FOA say about using existing cohorts and stored samples?
It encourages leveraging existing clinical cohorts and stored biospecimens/sample repositories where possible to support mechanistic questions about sleep/circadian disruption and HIV-related comorbidities.
What kinds of biological pathways and systems are mentioned as relevant mechanistic targets?
The FOA mentions connecting sleep/circadian measures to pathways involving immune or inflammatory signaling, autonomic function, metabolic changes, vascular biology, pulmonary physiology, and hematologic processes as relevant to HIV-related comorbidities.
What is the key "fit" signal that a proposed project aligns with this FOA?
A strong fit is a study that links HIV-associated sleep/circadian disruption to specific biological mechanisms and then relates those mechanisms to meaningful heart, lung, and/or blood outcomes, ideally using integrated clinical and biological methods and an interdisciplinary team.
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