Opportunity Information: Apply for RFA HD 18 032
The Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H) (UG3/UH3) funding opportunity (RFA-HD-18-032) is a National Institutes of Health (NIH) cooperative agreement designed to push forward research that improves HIV prevention and HIV care outcomes for adolescents and youth in low-to-middle income countries. The central public health goal is twofold: first, to reduce new HIV infections among adolescents who are at risk, and second, to strengthen the full continuum of HIV services for young people who are already living with HIV. That continuum includes finding undiagnosed infections, getting youth linked to clinical care, keeping them engaged over time, and ultimately achieving and sustaining long-term viral suppression.
A key feature of this opportunity is that the research must be conducted in resource-constrained settings with substantial HIV burden, as defined using UNAIDS epidemic density criteria. Specifically, eligible settings include countries that either have at least 200,000 people living with HIV where that number has not decreased by more than 5% over the last two consecutive years of available data, or countries with an HIV prevalence of 3% or higher. This requirement narrows the focus to places where the epidemic remains large or persistent, and where improvements in adolescent-focused prevention and treatment strategies could have major population-level impact.
The award mechanism is a phased innovation cooperative agreement (UG3/UH3), meaning applicants must plan for two connected stages of work and lay out clear objectives for both. The first stage (UG3) supports early project activities that demonstrate readiness to carry out the larger study. In practical terms, UG3 funds are intended to show that the team has the preparation, feasibility, infrastructure, and operational capacity to hit foundational milestones tied to the proposed research. Those milestones might involve establishing partnerships with clinics and community organizations, finalizing protocols, demonstrating recruitment or retention capacity, setting up data systems, or completing other start-up tasks that prove the study can be implemented as intended. Projects that successfully meet their UG3 milestones can then be administratively considered for transition to the second stage (UH3). The UH3 phase supports the full implementation of the research plan, with NICHD prioritizing transition for projects that show strong performance and readiness during UG3. Because this is a cooperative agreement rather than a standard grant, NIH involvement tends to be more hands-on, often including substantial programmatic input and milestone-based oversight.
Eligibility is broad and spans many organization types, reflecting the expectation that successful adolescent HIV research often requires collaboration across academic, clinical, governmental, and community systems. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. The announcement also highlights additional eligible categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based and community-based organizations are explicitly included, as are eligible federal agencies, U.S. territories or possessions, regional organizations, and non-U.S. (foreign) entities, which aligns with the international focus on low-to-middle income settings.
Administratively, this opportunity sits within NIH and is associated with CFDA numbers 93.273, 93.307, and 93.865, under the broad activity area of Health, Income Security and Social Services. It was created on October 18, 2017, with an original closing date of December 22, 2017. The listing does not specify an award ceiling or expected number of awards in the provided source details, which typically means applicants would need to consult the full FOA text or NIH postings for budget limits, project periods, and anticipated funding levels.
Overall, PATC3H is built to support rigorous, milestone-driven research that improves real-world prevention and care delivery for adolescents affected by HIV in high-burden, resource-limited contexts. The phased UG3/UH3 structure is meant to reduce implementation risk by requiring teams to prove feasibility and readiness before moving into full-scale study activities, while the cooperative agreement framework allows NIH to stay closely engaged to help keep complex, multi-site adolescent HIV research on track.Apply for RFA HD 18 032
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H) (UG3/UH3)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.307, 93.865.
- This funding opportunity was created on 2017-10-18.
- Applicants must submit their applications by 2017-12-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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